<mxfile host="app.diagrams.net"><diagram name="roadmap"><mxGraphModel dx="1200" dy="800" grid="1" gridSize="10" guides="1" tooltips="1" connect="1" arrows="1" fold="1" page="1" pageScale="1" pageWidth="1400" pageHeight="900" math="0" shadow="0">
  <root>
    <mxCell id="0" />
    <mxCell id="1" parent="0" />

    
    <mxCell id="node1" value="莽草酸制备成本高原料受限" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#D9EAD3;strokeColor=#6AA84F;fontSize=13;fontStyle=1;verticalAlign=middle;align=center;width=160;height=50;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="320" y="40" width="210" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="node2" value="克隆aroE基因至pWH1520载体" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#CFE2F3;strokeColor=#3C78D8;fontSize=13;fontStyle=1;verticalAlign=middle;align=center;width=200;height=50;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="320" y="162" width="210" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="node3" value="原生质体转化巨大芽孢杆菌" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#CFE2F3;strokeColor=#3C78D8;fontSize=13;fontStyle=1;verticalAlign=middle;align=center;width=200;height=50;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="320" y="284" width="210" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="node4" value="木糖诱导+7 L反应器发酵" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#CFE2F3;strokeColor=#3C78D8;fontSize=13;fontStyle=1;verticalAlign=middle;align=center;width=200;height=50;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="167" y="406" width="210" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="node5" value="碳源筛选+阴离子交换纯化" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#CFE2F3;strokeColor=#3C78D8;fontSize=13;fontStyle=1;verticalAlign=middle;align=center;width=200;height=50;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="40" y="528" width="210" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="node6" value="首个巨大芽孢杆菌aroE过表达菌株" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#FCE5CD;strokeColor=#E69138;fontSize=13;fontStyle=1;verticalAlign=middle;align=center;width=240;height=50;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="447" y="406" width="236" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="node7" value="产物产量12.54 g/L(果糖)" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#EAD1DC;strokeColor=#A64D79;fontSize=13;fontStyle=1;verticalAlign=middle;align=center;width=200;height=50;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="320" y="528" width="210" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="node8" value="产量提高8倍 酶活2.13倍" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#EAD1DC;strokeColor=#A64D79;fontSize=13;fontStyle=1;verticalAlign=middle;align=center;width=200;height=50;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="600" y="528" width="210" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="node9" value="aroE过表达+果糖为佳 具有工业潜力" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#D9D2E9;strokeColor=#674EA7;fontSize=14;fontStyle=1;verticalAlign=middle;align=center;width=260;height=55;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="300" y="650" width="250" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="edge1" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#6AA84F;fontSize=12;" edge="1" parent="1" source="node1" target="node2">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="edge1label" value="策略" style="edgeLabel;html=1;fontSize=11;fillColor=none;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;" vertex="1" parent="edge1">
      <mxGeometry relative="1" as="geometry">
        <mxPoint x="-10" y="0" as="offset" />
      </mxGeometry>
    </mxCell>

    
    <mxCell id="edge2" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#3C78D8;fontSize=12;" edge="1" parent="1" source="node2" target="node3">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>

    
    <mxCell id="edge3" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#3C78D8;fontSize=12;" edge="1" parent="1" source="node3" target="node4">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>

    
    <mxCell id="edge4" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#3C78D8;fontSize=12;" edge="1" parent="1" source="node4" target="node5">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>

    
    <mxCell id="edge5" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#E69138;fontSize=12;" edge="1" parent="1" source="node3" target="node6">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="edge5label" value="创新" style="edgeLabel;html=1;fontSize=11;fillColor=none;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;" vertex="1" parent="edge5">
      <mxGeometry relative="1" as="geometry">
        <mxPoint x="10" y="-5" as="offset" />
      </mxGeometry>
    </mxCell>

    
    <mxCell id="edge6" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#A64D79;fontSize=12;" edge="1" parent="1" source="node6" target="node7">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>

    
    <mxCell id="edge7" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#A64D79;fontSize=12;" edge="1" parent="1" source="node6" target="node8">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>

    
    <mxCell id="edge8" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#674EA7;fontSize=12;" edge="1" parent="1" source="node7" target="node9">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="edge8label" value="结论" style="edgeLabel;html=1;fontSize=11;fillColor=none;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;" vertex="1" parent="edge8">
      <mxGeometry relative="1" as="geometry">
        <mxPoint x="-10" y="-5" as="offset" />
      </mxGeometry>
    </mxCell>

    
    <mxCell id="edge9" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#674EA7;fontSize=12;" edge="1" parent="1" source="node8" target="node9">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>

    
    <mxCell id="edge10" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#674EA7;fontSize=12;dashed=1;" edge="1" parent="1" source="node5" target="node9">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
  </root>
</mxGraphModel></diagram></mxfile>