<mxfile host="app.diagrams.net"><diagram name="roadmap"><mxGraphModel dx="1200" dy="800" grid="1" gridSize="10" guides="1" tooltips="1" connect="1" arrows="1" fold="1" page="1" pageScale="1" pageWidth="1400" pageHeight="900" math="0" shadow="0">
<root>
<mxCell id="0" />
<mxCell id="1" parent="0" />
<mxCell id="node1" value="研究问题&#10;西松烷类能否&#10;经MVA途径合成" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#dae8fc;strokeColor=#6c8ebf;fontSize=12;fontStyle=1verticalAlign=middle;align=center;" vertex="1" parent="1">
<mxGeometry x="320" y="40" width="210" height="73" as="geometry" />
</mxCell>
<mxCell id="edge1" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#6c8ebf;" edge="1" source="node1" target="node2" parent="1">
<mxGeometry relative="1" as="geometry" />
</mxCell>
<mxCell id="node2" value="策略：优化合成酶&#10;强化MVA与GGPP供给" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#d5e8d4;strokeColor=#82b366;fontSize=12;fontStyle=1verticalAlign=middle;align=center;" vertex="1" parent="1">
<mxGeometry x="320" y="171" width="210" height="64" as="geometry" />
</mxCell>
<mxCell id="edge2" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#82b366;" edge="1" source="node2" target="node3" parent="1">
<mxGeometry relative="1" as="geometry" />
</mxCell>
<mxCell id="node3" value="AD/BD融合标签&#10;提高蛋白表达" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#ffe6cc;strokeColor=#d79b00;fontSize=12;fontStyle=1verticalAlign=middle;align=center;" vertex="1" parent="1">
<mxGeometry x="320" y="293" width="210" height="64" as="geometry" />
</mxCell>
<mxCell id="edge3" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#d79b00;" edge="1" source="node3" target="node4" parent="1">
<mxGeometry relative="1" as="geometry" />
</mxCell>
<mxCell id="node4" value="关键改造：&#10;BY-T20菌株表达CBTS1/CYP450" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#f8cecc;strokeColor=#b85450;fontSize=12;fontStyle=1verticalAlign=middle;align=center;" vertex="1" parent="1">
<mxGeometry x="320" y="415" width="210" height="64" as="geometry" />
</mxCell>
<mxCell id="edge4" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#b85450;" edge="1" source="node4" target="node5" parent="1">
<mxGeometry relative="1" as="geometry" />
</mxCell>
<mxCell id="node5" value="结果：CBT-ol&#10;摇瓶1.56 mg/L&#10;反应器10.02 mg/L" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#dae8fc;strokeColor=#6c8ebf;fontSize=12;fontStyle=0verticalAlign=middle;align=center;" vertex="1" parent="1">
<mxGeometry x="40" y="537" width="210" height="73" as="geometry" />
</mxCell>
<mxCell id="edge5" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#6c8ebf;" edge="1" source="node4" target="node5" parent="1">
<mxGeometry relative="1" as="geometry" />
</mxCell>
<mxCell id="node6" value="结果：CBT-diol&#10;摇瓶0.15 mg/L&#10;反应器1.05 mg/L" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#dae8fc;strokeColor=#6c8ebf;fontSize=12;fontStyle=0verticalAlign=middle;align=center;" vertex="1" parent="1">
<mxGeometry x="320" y="537" width="210" height="73" as="geometry" />
</mxCell>
<mxCell id="edge6" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#6c8ebf;" edge="1" source="node4" target="node6" parent="1">
<mxGeometry relative="1" as="geometry" />
</mxCell>
<mxCell id="node7" value="抗真菌活性&#10;CBT-diol抑制灰霉菌&#10;对酵母无抑制" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#d5e8d4;strokeColor=#82b366;fontSize=12;fontStyle=0verticalAlign=middle;align=center;" vertex="1" parent="1">
<mxGeometry x="600" y="537" width="210" height="73" as="geometry" />
</mxCell>
<mxCell id="edge7" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#82b366;" edge="1" source="node4" target="node7" parent="1">
<mxGeometry relative="1" as="geometry" />
</mxCell>
<mxCell id="node8" value="结论：酵母可作&#10;西松烷类合成宿主" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#e1d5e7;strokeColor=#9673a6;fontSize=12;fontStyle=1verticalAlign=middle;align=center;" vertex="1" parent="1">
<mxGeometry x="320" y="668" width="210" height="64" as="geometry" />
</mxCell>
<mxCell id="edge8" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#9673a6;" edge="1" source="node5" target="node8" parent="1">
<mxGeometry relative="1" as="geometry" />
</mxCell>
<mxCell id="edge9" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#9673a6;" edge="1" source="node6" target="node8" parent="1">
<mxGeometry relative="1" as="geometry" />
</mxCell>
<mxCell id="edge10" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#9673a6;" edge="1" source="node7" target="node8" parent="1">
<mxGeometry relative="1" as="geometry" />
</mxCell>
</root>
</mxGraphModel></diagram></mxfile>