<mxfile host="app.diagrams.net"><diagram name="roadmap"><mxGraphModel dx="1242" dy="794" grid="1" gridSize="10" guides="1" tooltips="1" connect="1" arrows="1" fold="1" page="1" pageScale="1" pageWidth="1200" pageHeight="800" math="0" shadow="0">
  <root>
    <mxCell id="0" />
    <mxCell id="1" parent="0" />

    
    <mxCell id="node1" value="木质纤维素水解瓶颈：游离酶效率低，需协同多酶体系" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#FFE6CC;strokeColor=#D79B00;fontSize=12;fontStyle=1;verticalAlign=middle;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="242" y="40" width="340" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="node2" value="毕赤酵母中自组装迷你纤维素体（scaffoldin+catalytic domain）" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#DAE8FC;strokeColor=#6C8EBF;fontSize=12;fontStyle=1;verticalAlign=middle;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="242" y="162" width="340" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="node3" value="导入xynB、cCelE、mini-CbpA基因至P. pastoris" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#DAE8FC;strokeColor=#6C8EBF;fontSize=12;fontStyle=0;verticalAlign=middle;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="248" y="284" width="327" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="node4" value="ADH2启动子在氧限制下驱动蛋白表达" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#D5E8D4;strokeColor=#82B366;fontSize=12;fontStyle=0;verticalAlign=middle;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="287" y="406" width="250" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="node5" value="cohesin-dockerin互作形成功能性迷你纤维素体" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#D5E8D4;strokeColor=#82B366;fontSize=12;fontStyle=0;verticalAlign=middle;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="252" y="528" width="320" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="node6" value="同步糖化发酵：木聚糖/CMC/预处理芒草→乙醇" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#FFF2CC;strokeColor=#D6B656;fontSize=12;fontStyle=1;verticalAlign=middle;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="78" y="650" width="313" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="node7" value="乙醇产量：1.08-1.18 g/L（较游离酶提高2.3-2.7倍）" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#F8CECC;strokeColor=#B85450;fontSize=12;fontStyle=0;verticalAlign=middle;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="40" y="772" width="340" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="node8" value="CaZyme比活力6.2 U/mg；协同效应达1.9倍" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#F8CECC;strokeColor=#B85450;fontSize=12;fontStyle=0;verticalAlign=middle;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="461" y="650" width="285" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="node9" value="整细胞催化剂实现木质纤维素高效降解与燃料生产" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#E1D5E7;strokeColor=#9673A6;fontSize=12;fontStyle=1;verticalAlign=middle;arcSize=12;" vertex="1" parent="1">
      <mxGeometry x="450" y="772" width="334" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="edge1" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;" edge="1" source="node1" target="node2" parent="1">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>

    
    <mxCell id="edge2" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;" edge="1" source="node2" target="node3" parent="1">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>

    
    <mxCell id="edge3" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;" edge="1" source="node3" target="node4" parent="1">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>

    
    <mxCell id="edge4" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;" edge="1" source="node4" target="node5" parent="1">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>

    
    <mxCell id="edge5" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;" edge="1" source="node5" target="node6" parent="1">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>

    
    <mxCell id="edge6" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;" edge="1" source="node6" target="node7" parent="1">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>

    
    <mxCell id="edge7" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;" edge="1" source="node5" target="node8" parent="1">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>

    
    <mxCell id="edge8" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=1;exitY=0.5;exitDx=0;exitDy=0;entryX=0;entryY=0.5;entryDx=0;entryDy=0;" edge="1" source="node7" target="node9" parent="1">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>

    
    <mxCell id="edge9" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;" edge="1" source="node8" target="node9" parent="1">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>

  </root>
</mxGraphModel></diagram></mxfile>