<mxfile host="app.diagrams.net"><diagram name="roadmap"><mxGraphModel dx="1200" dy="800" grid="0" gridSize="10" guides="1" tooltips="1" connect="1" arrows="1" fold="1" page="1" pageScale="1" pageWidth="1400" pageHeight="900" math="0" shadow="0">
  <root>
    <mxCell id="0" />
    <mxCell id="1" parent="0" />
    
    
    <mxCell id="n1" value="研究问题&lt;br&gt;毕赤酵母生长动力学不明" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="200" y="40" width="264" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n2" value="策略&lt;br&gt;批次实验+三模型拟合" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="72" y="214" width="215" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n3" value="关键改造&lt;br&gt;对比野生型与基因改造菌株" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="40" y="388" width="278" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n4" value="结果1&lt;br&gt;甘油：Haldane模型最优" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="50" y="562" width="236" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n5" value="结果2&lt;br&gt;甲醇：CPM模型最优" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="64" y="736" width="210" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n6" value="结果3&lt;br&gt;基因改造提高最适生长速率" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="356" y="562" width="257" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n7" value="模型应用&lt;br&gt;优化fed-batch补料策略" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="344" y="736" width="257" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n8" value="结论&lt;br&gt;动力学模型指导过程优化" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="388" y="388" width="236" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n9" value="基础分析&lt;br&gt;碳源与菌株交互影响" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="356" y="214" width="236" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="e1" edge="1" parent="1" source="n1" target="n2" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e2" edge="1" parent="1" source="n2" target="n3" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e3" edge="1" parent="1" source="n3" target="n4" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e4" edge="1" parent="1" source="n3" target="n6" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e5" edge="1" parent="1" source="n4" target="n5" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e6" edge="1" parent="1" source="n5" target="n7" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=1;exitY=0.5;exitDx=0;exitDy=0;entryX=0;entryY=0.5;entryDx=0;entryDy=0;">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e7" edge="1" parent="1" source="n6" target="n7" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e8" edge="1" parent="1" source="n7" target="n8" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0;exitY=0.5;exitDx=0;exitDy=0;entryX=0;entryY=0.5;entryDx=0;entryDy=0;dashed=1;dashed=1;dashed=1;dashed=1;">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e9" edge="1" parent="1" source="n1" target="n9" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e10" edge="1" parent="1" source="n9" target="n8" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
  </root>
</mxGraphModel></diagram></mxfile>