<mxfile host="app.diagrams.net"><diagram name="roadmap"><mxGraphModel dx="1080" dy="720" grid="1" gridSize="10" guides="1" tooltips="1" connect="1" arrows="1" fold="1" page="1" pageScale="1" pageWidth="1400" pageHeight="800" math="0" shadow="0">
  <root>
    <mxCell id="0" />
    <mxCell id="1" parent="0" />
    
    <mxCell id="n1" value="问题：GPP/GGPP前体供应不足" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#FFE6CC;strokeColor=#D79B00;fontSize=13;fontStyle=1;fontColor=#6B3A00;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="193" y="40" width="210" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n2" value="策略：构建模块化合成操纵子" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#E1D5E7;strokeColor=#9673A6;fontSize=13;fontStyle=1;fontColor=#4C2A63;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="40" y="162" width="210" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n3" value="改造：IspA定点突变" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#FFF2CC;strokeColor=#D6B656;fontSize=13;fontStyle=1;fontColor=#6B5300;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="53" y="284" width="210" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n4" value="改造：共表达dxs+IPIHp" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#F8CECC;strokeColor=#B85450;fontSize=13;fontStyle=1;fontColor=#6B1A1A;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="53" y="406" width="210" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n5" value="关键改造：SOE操纵子" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#D5E8D4;strokeColor=#82B366;fontSize=13;fontStyle=1;fontColor=#1A4A1A;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="53" y="528" width="210" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n6" value="结果：单萜/二萜体内生产" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#DAE3F3;strokeColor=#6C8EBF;fontSize=13;fontStyle=1;fontColor=#1A3A6B;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="333" y="528" width="210" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n7" value="结果：番茄红素产量提升6倍" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#DAE3F3;strokeColor=#6C8EBF;fontSize=13;fontStyle=1;fontColor=#1A3A6B;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="333" y="406" width="210" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n8" value="结果：IspA突变体酶活验证" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#DAE3F3;strokeColor=#6C8EBF;fontSize=13;fontStyle=1;fontColor=#1A3A6B;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="333" y="284" width="210" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n9" value="结论：前体平台助力萜类药物开发" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#D5E8D4;strokeColor=#82B366;fontSize=13;fontStyle=1;fontColor=#1A4A1A;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="320" y="162" width="236" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="e1" edge="1" parent="1" source="n1" target="n2" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#B85450;"> 
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e2" edge="1" parent="1" source="n2" target="n3" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#9673A6;"> 
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e3" edge="1" parent="1" source="n3" target="n4" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#B85450;"> 
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e4" edge="1" parent="1" source="n4" target="n5" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#82B366;"> 
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e5" edge="1" parent="1" source="n5" target="n6" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=1;exitY=0.5;exitDx=0;exitDy=0;entryX=0;entryY=0.5;entryDx=0;entryDy=0;strokeColor=#82B366;"> 
      <mxGeometry relative="1" as="geometry">
        </mxGeometry>
    </mxCell>
    
    <mxCell id="e6" edge="1" parent="1" source="n7" target="n6" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#6C8EBF;"> 
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e7" edge="1" parent="1" source="n8" target="n7" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#6C8EBF;"> 
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e8" edge="1" parent="1" source="n9" target="n8" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#82B366;"> 
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e9" edge="1" parent="1" source="n1" target="n9" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#B85450;"> 
      <mxGeometry relative="1" as="geometry">
        </mxGeometry>
    </mxCell>
    
  </root>
</mxGraphModel></diagram></mxfile>