<mxfile host="app.diagrams.net"><diagram name="roadmap"><mxGraphModel dx="1200" dy="800" grid="1" gridSize="10" guides="1" tooltips="1" connect="1" arrows="1" fold="1" page="1" pageScale="1" pageWidth="1400" pageHeight="900" math="0" shadow="0">
  <root>
    <mxCell id="0" />
    <mxCell id="1" parent="0" />
    <mxCell id="node1" value="研究问题：多限速酶活性不足导致异戊二烯产量低" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#FFF2CC;strokeColor=#D6B656;fontSize=13;fontStyle=1;absoluteArcSize=10;arcSize=6;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="248" y="40" width="334" height="64" as="geometry" />
    </mxCell>
    <mxCell id="node2" value="策略：DXS/DXR/IDI 定向共进化+模块化途径工程" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#DEEBF7;strokeColor=#548235;fontSize=13;fontStyle=1;absoluteArcSize=10;arcSize=6;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="252" y="214" width="327" height="64" as="geometry" />
    </mxCell>
    <mxCell id="edge1" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;" edge="1" parent="1" source="node1" target="node2">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="node3" value="高通量筛选：番茄红素颜色指示筛选正向突变体" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#E2EFDA;strokeColor=#375623;fontSize=13;fontStyle=1;absoluteArcSize=10;arcSize=6;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="255" y="388" width="320" height="64" as="geometry" />
    </mxCell>
    <mxCell id="edge2" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;" edge="1" parent="1" source="node2" target="node3">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="node4" value="改造1：获得正向突变体 dxs/dxr/idi-1-6" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#FCE4D6;strokeColor=#C55A11;fontSize=13;fontStyle=1;absoluteArcSize=10;arcSize=6;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="68" y="562" width="285" height="64" as="geometry" />
    </mxCell>
    <mxCell id="edge3" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;" edge="1" parent="1" source="node3" target="node4">
      <mxGeometry relative="1" as="geometry">
        </mxGeometry>
    </mxCell>
    <mxCell id="node5" value="关键结果1：蛋白工程使番茄红素提80%，异戊二烯提60%" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#D9E1F2;strokeColor=#1F3864;fontSize=13;fontStyle=1;absoluteArcSize=10;arcSize=6;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="40" y="736" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="edge4" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;" edge="1" parent="1" source="node4" target="node5">
      <mxGeometry relative="1" as="geometry">
        </mxGeometry>
    </mxCell>
    <mxCell id="node6" value="改造2：模块化启动子工程（P_Trc,P_Ara，诱导剂优化）" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#FCE4D6;strokeColor=#C55A11;fontSize=13;fontStyle=1;absoluteArcSize=10;arcSize=6;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="422" y="562" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="edge5" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;" edge="1" parent="1" source="node3" target="node6">
      <mxGeometry relative="1" as="geometry">
        </mxGeometry>
    </mxCell>
    <mxCell id="node7" value="关键结果2：组合策略使异戊二烯产量达17.5mg/L，提高4.72倍" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#D9E1F2;strokeColor=#1F3864;fontSize=13;fontStyle=1;absoluteArcSize=10;arcSize=6;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="450" y="736" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="edge6" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;" edge="1" parent="1" source="node6" target="node7">
      <mxGeometry relative="1" as="geometry">
        </mxGeometry>
    </mxCell>
    <mxCell id="node8" value="结论：组合策略可推广至其他异戊二烯类及天然产物" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#FFF2CC;strokeColor=#D6B656;fontSize=13;fontStyle=1;absoluteArcSize=10;arcSize=6;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="245" y="910" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="edge7" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;" edge="1" parent="1" source="node5" target="node8">
      <mxGeometry relative="1" as="geometry">
        </mxGeometry>
    </mxCell>
    <mxCell id="edge8" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;" edge="1" parent="1" source="node7" target="node8">
      <mxGeometry relative="1" as="geometry">
        </mxGeometry>
    </mxCell>
  </root>
</mxGraphModel></diagram></mxfile>