<mxfile host="app.diagrams.net"><diagram name="roadmap"><mxGraphModel>
  <root>
    <mxCell id="0" />
    <mxCell id="1" parent="0" />
    <mxCell id="node_problem" value="研究问题：MEP途径基因过表达如何影响C30类胡萝卜素产量？" style="rounded=1;whiteSpace=wrap;html=0;fillColor=#dae8fc;strokeColor=#6c8ebf;fontSize=12;fontStyle=2verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="245" y="40" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="node_strategy" value="策略：分A/B组逐步构建合成操纵子过表达MEP途径基因" style="rounded=1;whiteSpace=wrap;html=0;fillColor=#d5e8d4;strokeColor=#82b366;fontSize=12;fontStyle=2verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="245" y="162" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="node_operonA" value="关键改造A：dxs, ispD, ispF, ispH系统过表达（p04SDFH）" style="rounded=1;whiteSpace=wrap;html=0;fillColor=#fff2cc;strokeColor=#d6b656;fontSize=11verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="40" y="284" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="node_operonB" value="关键改造B：ispC, ispE, ispG, ispA系统过表达（p04CEGA）" style="rounded=1;whiteSpace=wrap;html=0;fillColor=#fff2cc;strokeColor=#d6b656;fontSize=11verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="450" y="284" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="node_result" value="结果：产量从0.60提升至10.65 mg/g dcw（17.8倍）" style="rounded=1;whiteSpace=wrap;html=0;fillColor=#f8cecc;strokeColor=#b85450;fontSize=12;fontStyle=2verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="245" y="406" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="node_conclusion" value="结论：系统过表达MEP途径基因有效增强类异戊二烯前体供应，奠定细胞工厂基础" style="rounded=1;whiteSpace=wrap;html=0;fillColor=#e1d5e7;strokeColor=#9673a6;fontSize=12;fontStyle=2verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="245" y="528" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="edge_problem_strategy" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="node_problem" target="node_strategy">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="edge_strategy_operonA" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="node_strategy" target="node_operonA">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="edge_strategy_operonB" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="node_strategy" target="node_operonB">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="edge_operonA_result" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="node_operonA" target="node_result">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="edge_operonB_result" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="node_operonB" target="node_result">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="edge_result_conclusion" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="node_result" target="node_conclusion">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
  </root>
</mxGraphModel></diagram></mxfile>