<mxfile host="app.diagrams.net"><diagram name="roadmap"><mxGraphModel dx="1500" dy="800" grid="1" gridSize="10" guides="1" tooltips="1" connect="1" arrows="1" fold="1" page="1" pageScale="1" pageWidth="1600" pageHeight="900" math="0" shadow="0">
  <root>
    <mxCell id="0" />
    <mxCell id="1" parent="0" />
    
    
    <mxCell id="n1" value="新类胡萝卜素基因结构功能多样性与新颖性" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#dae8fc;strokeColor=#6c8ebf;fontSize=13;fontStyle=1;arcSize=8;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="446" y="40" width="292" height="64" as="geometry" />
    </mxCell>
    
    
    <mxCell id="n2" value="策略：基因组测序+功能克隆+系统发育+异源表达验证" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#fff2cc;strokeColor=#d6b656;fontSize=12;arcSize=8;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="422" y="214" width="340" height="64" as="geometry" />
    </mxCell>
    
    
    <mxCell id="n3" value="关键改造：新型环化酶（CrtYm/CrtLm/Fusion CrtYcd/CruA）" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#f8cecc;strokeColor=#b85450;fontSize=12;arcSize=8;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="40" y="388" width="340" height="64" as="geometry" />
    </mxCell>
    
    
    <mxCell id="n4" value="关键改造：酮醇酶与氧化酶（CrtO/CrtNb/CrtG/P450羟化酶）" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#f8cecc;strokeColor=#b85450;fontSize=12;arcSize=8;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="450" y="388" width="340" height="64" as="geometry" />
    </mxCell>
    
    
    <mxCell id="n5" value="关键改造：多顺式异构酶（CrtH/CrtISO）" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#f8cecc;strokeColor=#b85450;fontSize=12;arcSize=8;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="860" y="388" width="285" height="64" as="geometry" />
    </mxCell>
    
    
    <mxCell id="n6" value="结果：单环化产物+融合环化酶+新型底物特异性" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#d5e8d4;strokeColor=#82b366;fontSize=12;arcSize=8;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="60" y="562" width="320" height="64" as="geometry" />
    </mxCell>
    
    
    <mxCell id="n7" value="结果：对称/不对称酮化+醛基氧化+羟基化产物" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#d5e8d4;strokeColor=#82b366;fontSize=12;arcSize=8;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="450" y="562" width="313" height="64" as="geometry" />
    </mxCell>
    
    
    <mxCell id="n8" value="结果：poly-cis→全反式异构化；同源性高" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#d5e8d4;strokeColor=#82b366;fontSize=12;arcSize=8;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="833" y="562" width="292" height="64" as="geometry" />
    </mxCell>
    
    
    <mxCell id="n9" value="结论：基因家族拓展+工程应用潜力+序列同源预测需谨慎" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#e1d5e7;strokeColor=#9673a6;fontSize=13;fontStyle=1;arcSize=8;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="422" y="736" width="340" height="64" as="geometry" />
    </mxCell>
    
    
    <mxCell id="e1-2" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;" edge="1" parent="1" source="n1" target="n2">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e2-3" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;" edge="1" parent="1" source="n2" target="n3">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e2-4" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;" edge="1" parent="1" source="n2" target="n4">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e2-5" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;" edge="1" parent="1" source="n2" target="n5">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e3-6" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;" edge="1" parent="1" source="n3" target="n6">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e4-7" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;" edge="1" parent="1" source="n4" target="n7">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e5-8" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;" edge="1" parent="1" source="n5" target="n8">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e6-9" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;" edge="1" parent="1" source="n6" target="n9">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e7-9" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;" edge="1" parent="1" source="n7" target="n9">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e8-9" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;" edge="1" parent="1" source="n8" target="n9">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
  </root>
</mxGraphModel></diagram></mxfile>