<mxfile host="app.diagrams.net"><diagram name="roadmap"><mxGraphModel dx="1200" dy="800" grid="1" gridSize="10" guides="1" tooltips="1" connect="1" arrows="1" fold="1" page="1" pageScale="1" pageWidth="1400" pageHeight="900" math="0" shadow="0">
<root>
  <mxCell id="0" />
  <mxCell id="1" parent="0" />
  <mxCell id="node1" value="研究问题:基因剂量与Mut表型联合影响未明" style="shape=cloud;whiteSpace=wrap;html=1;fillColor=#fff2cc;strokeColor=#d6b656;fontSize=13;verticalAlign=middle;align=center;" vertex="1" parent="1">
    <mxGeometry x="571" y="40" width="292" height="64" as="geometry" />
  </mxCell>
  <mxCell id="edge1" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;" edge="1" parent="1" source="node1" target="node2">
    <mxGeometry relative="1" as="geometry" />
  </mxCell>
  <mxCell id="node2" value="策略:构建四株组合菌株系统比较" style="shape=process;whiteSpace=wrap;html=1;fillColor=#dae8fc;strokeColor=#6c8ebf;fontSize=13;perimeter=orthogonalPerimeter;verticalAlign=middle;align=center;" vertex="1" parent="1">
    <mxGeometry x="602" y="214" width="229" height="64" as="geometry" />
  </mxCell>
  <mxCell id="edge2" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;" edge="1" parent="1" source="node2" target="node3">
    <mxGeometry relative="1" as="geometry" />
  </mxCell>
  <mxCell id="node3" value="关键改造:四种菌株构建与验证" style="shape=process;whiteSpace=wrap;html=1;fillColor=#dae8fc;strokeColor=#6c8ebf;fontSize=13;perimeter=orthogonalPerimeter;verticalAlign=middle;align=center;" vertex="1" parent="1">
    <mxGeometry x="610" y="388" width="215" height="64" as="geometry" />
  </mxCell>
  <mxCell id="edge3" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;" edge="1" parent="1" source="node3" target="node4">
    <mxGeometry relative="1" as="geometry" />
  </mxCell>
  <mxCell id="node4" value="结果:Mut⁺体积产率更高1.34倍" style="shape=process;whiteSpace=wrap;html=1;fillColor=#d5e8d4;strokeColor=#82b366;fontSize=13;perimeter=orthogonalPerimeter;verticalAlign=middle;align=center;" vertex="1" parent="1">
    <mxGeometry x="40" y="562" width="222" height="64" as="geometry" />
  </mxCell>
  <mxCell id="edge4" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;" edge="1" parent="1" source="node4" target="node5">
    <mxGeometry relative="1" as="geometry" />
  </mxCell>
  <mxCell id="node5" value="结论:Muts比活高,多拷贝有负担" style="shape=parallelogram;whiteSpace=wrap;html=1;fillColor=#f8cecc;strokeColor=#b85450;fontSize=13;perimeter=orthogonalPerimeter;verticalAlign=middle;align=center;" vertex="1" parent="1">
    <mxGeometry x="606" y="736" width="222" height="64" as="geometry" />
  </mxCell>
  <mxCell id="node6" value="Mut⁺单拷贝ROL菌株" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#e1d5e7;strokeColor=#9673a6;fontSize=12;verticalAlign=middle;align=center;" vertex="1" parent="1">
    <mxGeometry x="332" y="562" width="210" height="64" as="geometry" />
  </mxCell>
  <mxCell id="node7" value="Mut⁺多拷贝ROL菌株" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#e1d5e7;strokeColor=#9673a6;fontSize=12;verticalAlign=middle;align=center;" vertex="1" parent="1">
    <mxGeometry x="612" y="562" width="210" height="64" as="geometry" />
  </mxCell>
  <mxCell id="node8" value="Muts单拷贝ROL菌株" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#e1d5e7;strokeColor=#9673a6;fontSize=12;verticalAlign=middle;align=center;" vertex="1" parent="1">
    <mxGeometry x="892" y="562" width="210" height="64" as="geometry" />
  </mxCell>
  <mxCell id="node9" value="Muts多拷贝ROL菌株(23-24拷贝)" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#e1d5e7;strokeColor=#9673a6;fontSize=12;verticalAlign=middle;align=center;" vertex="1" parent="1">
    <mxGeometry x="1172" y="562" width="222" height="64" as="geometry" />
  </mxCell>
  <mxCell id="edge5" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;dashed=1;" edge="1" parent="1" source="node3" target="node6">
    <mxGeometry relative="1" as="geometry" />
  </mxCell>
  <mxCell id="edge6" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;dashed=1;" edge="1" parent="1" source="node3" target="node7">
    <mxGeometry relative="1" as="geometry" />
  </mxCell>
  <mxCell id="edge7" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;dashed=1;" edge="1" parent="1" source="node3" target="node8">
    <mxGeometry relative="1" as="geometry" />
  </mxCell>
  <mxCell id="edge8" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=12;dashed=1;" edge="1" parent="1" source="node3" target="node9">
    <mxGeometry relative="1" as="geometry" />
  </mxCell>
</root>
</mxGraphModel></diagram></mxfile>