<mxfile host="app.diagrams.net"><diagram name="roadmap"><mxGraphModel dx="1200" dy="800" grid="1" gridSize="10" guides="1" tooltips="1" connect="1" arrows="1" fold="1" page="1" pageScale="1" pageWidth="1400" pageHeight="900" math="0" shadow="0">
  <root>
    <mxCell id="0" />
    <mxCell id="1" parent="0" />

    
    <mxCell id="n1" value="问题：甘油厌氧发酵&lt;br&gt;氧化还原平衡挑战" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#F8CECC;strokeColor=#B85450;fontSize=13;fontStyle=1;arcSize=10;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="269" y="40" width="292" height="64" as="geometry" />
    </mxCell>
    <mxCell id="n2" value="策略：利用天然菌与工程菌&lt;br&gt;系统综述多种产品途径" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#DAE8FC;strokeColor=#6C8EBF;fontSize=13;fontStyle=1;arcSize=10;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="40" y="162" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="n3" value="关键：甘油高还原度κ=4.67&lt;br&gt;优于糖类底物" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#D5E8D4;strokeColor=#82B366;fontSize=13;fontStyle=1;arcSize=10;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="54" y="284" width="313" height="64" as="geometry" />
    </mxCell>
    <mxCell id="n4" value="代谢工程改造大肠杆菌&lt;br&gt;1,2-PDO-乙醇模型" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#FFF2CC;strokeColor=#D6B656;fontSize=13;fontStyle=1;arcSize=10;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="57" y="406" width="306" height="64" as="geometry" />
    </mxCell>
    <mxCell id="n5" value="代表性结果：&lt;br&gt;1,3-PDO 93.7 g/L · 琥珀酸 29.3 g/L&lt;br&gt;丙酸 42 g/L · 乙醇 25.2 g/L&lt;br&gt;正丁醇 17.8 g/L" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#E1D5E7;strokeColor=#9673A6;fontSize=13;fontStyle=1;arcSize=10;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="450" y="162" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="n6" value="关键改造示例：&lt;br&gt;gldA↑·pck↑·pflB−&lt;br&gt;ptsI−·frdC−·适应性进化" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#FFE6CC;strokeColor=#D79B00;fontSize=13;fontStyle=1;arcSize=10;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="436" y="284" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="n7" value="产物：&lt;br&gt;1,3-PDO · 1,2-PDO · 琥珀酸&lt;br&gt;丙酸 · 乙醇 · 氢气 · 正丁醇" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#D4E1F5;strokeColor=#6C8EBF;fontSize=13;fontStyle=1;arcSize=10;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="433" y="406" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="n8" value="结论：甘油厌氧发酵&lt;br&gt;燃料与化学品高效生产平台" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#F8CECC;strokeColor=#B85450;fontSize=14;fontStyle=1;arcSize=10;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="245" y="528" width="340" height="64" as="geometry" />
    </mxCell>

    
    <mxCell id="e1" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#B85450;" edge="1" parent="1" source="n1" target="n2">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="e2" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#B85450;" edge="1" parent="1" source="n2" target="n3">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="e3" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#B85450;" edge="1" parent="1" source="n3" target="n4">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="e4" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#6C8EBF;" edge="1" parent="1" source="n1" target="n5">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="e5" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0;exitY=0.5;exitDx=0;exitDy=0;entryX=0;entryY=0.5;entryDx=0;entryDy=0;dashed=1;dashed=1;strokeColor=#6C8EBF;" edge="1" parent="1" source="n4" target="n6">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="e6" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#6C8EBF;" edge="1" parent="1" source="n5" target="n6">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="e7" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#6C8EBF;" edge="1" parent="1" source="n6" target="n7">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="e8" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#B85450;" edge="1" parent="1" source="n7" target="n8">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
  </root>
</mxGraphModel></diagram></mxfile>