<mxfile host="app.diagrams.net"><diagram name="roadmap"><mxGraphModel dx="1200" dy="800" grid="1" gridSize="10" guides="1" tooltips="1" connect="1" arrows="1" fold="1" page="1" pageScale="1" pageWidth="1400" pageHeight="900" math="0" shadow="0">
  <root>
    <mxCell id="0" />
    <mxCell id="1" parent="0" />
    
    
    <mxCell id="n1" value="研究问题&#10;单一途径局限性" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#dae8fc;strokeColor=#6c8ebf;fontSize=14;fontStyle=1;verticalAlign=middle;arcSize=20;" vertex="1" parent="1">
      <mxGeometry x="320" y="40" width="210" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n2" value="策略设计&#10;途径协同+模型指导" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#d5e8d4;strokeColor=#82b366;fontSize=14;fontStyle=1;verticalAlign=middle;arcSize=20;" vertex="1" parent="1">
      <mxGeometry x="180" y="162" width="210" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n3" value="关键改造&#10;基因敲除/过表达" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#fff2cc;strokeColor=#d6b656;fontSize=14;fontStyle=1;verticalAlign=middle;arcSize=20;" vertex="1" parent="1">
      <mxGeometry x="40" y="284" width="210" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n4" value="验证策略&#10;通量比平衡计算" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#f8cecc;strokeColor=#b85450;fontSize=14;fontStyle=1;verticalAlign=middle;arcSize=20;" vertex="1" parent="1">
      <mxGeometry x="180" y="406" width="210" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n5" value="结果对比&#10;双途径vs单途径" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#e1d5e7;strokeColor=#9673a6;fontSize=14;fontStyle=1;verticalAlign=middle;arcSize=20;" vertex="1" parent="1">
      <mxGeometry x="460" y="162" width="210" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n6" value="核心数据&#10;产量产率显著提升" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#d9e2f3;strokeColor=#6ea8dc;fontSize=14;fontStyle=1;verticalAlign=middle;arcSize=20;" vertex="1" parent="1">
      <mxGeometry x="320" y="284" width="210" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n7" value="冗余分析&#10;TCA/Z酸敲除影响" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#d9d2e9;strokeColor=#8e7cc3;fontSize=14;fontStyle=1;verticalAlign=middle;arcSize=20;" vertex="1" parent="1">
      <mxGeometry x="460" y="406" width="210" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n8" value="工艺优化&#10;连续生产11天" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#ead1dc;strokeColor=#a64d79;fontSize=14;fontStyle=1;verticalAlign=middle;arcSize=20;" vertex="1" parent="1">
      <mxGeometry x="320" y="528" width="210" height="64" as="geometry" />
    </mxCell>
    
    <mxCell id="n9" value="结论&#10;途径协同作为通用原则" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#cce5ff;strokeColor=#2980b9;fontSize=15;fontStyle=1;verticalAlign=middle;arcSize=20;" vertex="1" parent="1">
      <mxGeometry x="600" y="284" width="210" height="64" as="geometry" />
    </mxCell>
    
    
    
    <mxCell id="e1" value="" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="n1" target="n2">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e2" value="" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="n2" target="n3">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e3" value="" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="n3" target="n4">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    
    <mxCell id="e4" value="" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="n1" target="n5">
      <mxGeometry relative="1" as="geometry">
        </mxGeometry>
    </mxCell>
    
    <mxCell id="e5" value="" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="n2" target="n6">
      <mxGeometry relative="1" as="geometry">
        </mxGeometry>
    </mxCell>
    
    <mxCell id="e6" value="" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="n3" target="n7">
      <mxGeometry relative="1" as="geometry">
        </mxGeometry>
    </mxCell>
    
    <mxCell id="e7" value="" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="n4" target="n8">
      <mxGeometry relative="1" as="geometry">
        </mxGeometry>
    </mxCell>
    
    
    <mxCell id="e8" value="" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="n5" target="n6">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e9" value="" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="n6" target="n7">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    <mxCell id="e10" value="" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="n7" target="n8">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    
    
    <mxCell id="e11" value="" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="n5" target="n9">
      <mxGeometry relative="1" as="geometry">
        </mxGeometry>
    </mxCell>
    
    <mxCell id="e12" value="" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=1;exitY=0.5;exitDx=0;exitDy=0;entryX=0;entryY=0.5;entryDx=0;entryDy=0;strokeColor=#333333;" edge="1" parent="1" source="n6" target="n9">
      <mxGeometry relative="1" as="geometry">
        </mxGeometry>
    </mxCell>
    
    <mxCell id="e13" value="" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0;exitY=0.5;exitDx=0;exitDy=0;entryX=0;entryY=0.5;entryDx=0;entryDy=0;dashed=1;dashed=1;dashed=1;dashed=1;strokeColor=#333333;" edge="1" parent="1" source="n7" target="n9">
      <mxGeometry relative="1" as="geometry">
        </mxGeometry>
    </mxCell>
    
    <mxCell id="e14" value="" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0;exitY=0.5;exitDx=0;exitDy=0;entryX=0;entryY=0.5;entryDx=0;entryDy=0;dashed=1;dashed=1;dashed=1;dashed=1;strokeColor=#333333;" edge="1" parent="1" source="n8" target="n9">
      <mxGeometry relative="1" as="geometry">
        </mxGeometry>
    </mxCell>
    
  </root>
</mxGraphModel></diagram></mxfile>