<mxfile host="app.diagrams.net"><diagram name="roadmap"><mxGraphModel dx="1024" dy="768" grid="1" gridSize="10" guides="1" tooltips="1" connect="1" arrows="1" fold="1" page="1" pageScale="1" pageWidth="1169" pageHeight="826" math="0" shadow="0">
<root>
<mxCell id="0" />
<mxCell id="1" parent="0" />


<mxCell id="node1" value="CDPS途径未充分开发&#10;DKP-萜烯机制不清楚" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#F8CECC;strokeColor=#B85450;fontSize=12;fontStyle=1;verticalAlign=middle;align=center;arcSize=10;" vertex="1" parent="1">
<mxGeometry x="326" y="40" width="210" height="64" as="geometry" />
</mxCell>


<mxCell id="node2" value="基因组挖掘+比较基因组&#10;异源表达+基因失活+体外生化" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#FFF2CC;strokeColor=#D6B656;fontSize=12;fontStyle=0;verticalAlign=middle;align=center;arcSize=10;" vertex="1" parent="1">
<mxGeometry x="326" y="162" width="210" height="64" as="geometry" />
</mxCell>


<mxCell id="node3" value="发现3个CDPS基因簇&#10;DmtB1新酶（混杂底物）&#10;定点突变改造" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#D5E8D4;strokeColor=#82B366;fontSize=12;fontStyle=0;verticalAlign=middle;align=center;arcSize=10;" vertex="1" parent="1">
<mxGeometry x="40" y="284" width="210" height="90" as="geometry" />
</mxCell>


<mxCell id="node4" value="DmtB1突变体分析&#10;L185F→cWA↑2.4倍,cWP↑3.1倍&#10;V205M→cWL↑2.3倍" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#DAE3F3;strokeColor=#6C8EBF;fontSize=11;verticalAlign=middle;align=center;arcSize=10;" vertex="1" parent="1">
<mxGeometry x="320" y="284" width="222" height="90" as="geometry" />
</mxCell>


<mxCell id="node5" value="DmtC1异戊烯基转移酶&#10;FPP连接DKP&#10;DmtA1膜结合环化酶&#10;多位点突变失活" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#DAE3F3;strokeColor=#6C8EBF;fontSize=11;verticalAlign=middle;align=center;arcSize=10;" vertex="1" parent="1">
<mxGeometry x="612" y="284" width="210" height="90" as="geometry" />
</mxCell>


<mxCell id="node6" value="阐明CDPS-DKP-萜烯&#10;三步组装途径" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#E1D5E7;strokeColor=#9673A6;fontSize=12;fontStyle=1;verticalAlign=middle;align=center;arcSize=10;" vertex="1" parent="1">
<mxGeometry x="326" y="432" width="210" height="64" as="geometry" />
</mxCell>


<mxCell id="node7" value="拓展CDPS机制认知&#10;奠定组合生物合成基础" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#F8CECC;strokeColor=#B85450;fontSize=12;fontStyle=1;verticalAlign=middle;align=center;arcSize=10;" vertex="1" parent="1">
<mxGeometry x="326" y="554" width="210" height="64" as="geometry" />
</mxCell>


<mxCell id="e1" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=11;strokeColor=#B85450;" edge="1" parent="1" source="node1" target="node2">
<mxGeometry relative="1" as="geometry" />
</mxCell>

<mxCell id="e2" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=11;strokeColor=#82B366;" edge="1" parent="1" source="node2" target="node3">
<mxGeometry relative="1" as="geometry" />
<mxPoint x="360" y="200" as="sourcePoint" />
</mxCell>

<mxCell id="e3" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=11;strokeColor=#82B366;" edge="1" parent="1" source="node2" target="node4">
<mxGeometry relative="1" as="geometry" />
</mxCell>

<mxCell id="e4" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=11;strokeColor=#82B366;" edge="1" parent="1" source="node2" target="node5">
<mxGeometry relative="1" as="geometry" />
</mxCell>

<mxCell id="e5" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=11;strokeColor=#9673A6;" edge="1" parent="1" source="node3" target="node6">
<mxGeometry relative="1" as="geometry" />
</mxCell>

<mxCell id="e6" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=11;strokeColor=#9673A6;" edge="1" parent="1" source="node4" target="node6">
<mxGeometry relative="1" as="geometry" />
</mxCell>

<mxCell id="e7" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=11;strokeColor=#9673A6;" edge="1" parent="1" source="node5" target="node6">
<mxGeometry relative="1" as="geometry" />
</mxCell>

<mxCell id="e8" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;fontSize=11;strokeColor=#B85450;" edge="1" parent="1" source="node6" target="node7">
<mxGeometry relative="1" as="geometry" />
</mxCell>
</root>
</mxGraphModel></diagram></mxfile>