<mxfile host="app.diagrams.net"><diagram name="roadmap"><mxGraphModel dx="1422" dy="794" grid="1" gridSize="10" guides="1" tooltips="1" connect="1" arrows="1" fold="1" page="1" pageScale="1" pageWidth="1169" pageHeight="826" math="0" shadow="0">
  <root>
    <mxCell id="0" />
    <mxCell id="1" parent="0" />
    <mxCell id="Node1" value="研究问题：鲨鱼角鲨烯来源不可持续，需替代品" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#dae8fc;strokeColor=#6c8ebf;fontSize=16;fontStyle=1;verticalAlign=middle;align=center;arcSize=10;" vertex="1" parent="1">
      <mxGeometry x="228" y="40" width="320" height="64" as="geometry" />
    </mxCell>
    <mxCell id="Node2" value="策略：生物合成β-法尼烯，化学合成角鲨烯类似物文库" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#d5e8d4;strokeColor=#82b366;fontSize=16;fontStyle=0;verticalAlign=middle;align=center;arcSize=10;" vertex="1" parent="1">
      <mxGeometry x="44" y="162" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="Node3" value="关键改造1：工程化酵母发酵产β-法尼烯" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#ffe6cc;strokeColor=#d79b00;fontSize=16;fontStyle=0;verticalAlign=middle;align=center;arcSize=10;" vertex="1" parent="1">
      <mxGeometry x="454" y="162" width="278" height="64" as="geometry" />
    </mxCell>
    <mxCell id="Node4" value="关键改造2：合成类似物并制备水包油纳米乳液" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#ffe6cc;strokeColor=#d79b00;fontSize=16;fontStyle=0;verticalAlign=middle;align=center;arcSize=10;" vertex="1" parent="1">
      <mxGeometry x="40" y="284" width="313" height="64" as="geometry" />
    </mxCell>
    <mxCell id="Node5" value="关键改造3：期望函数多维度综合评分" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#ffe6cc;strokeColor=#d79b00;fontSize=16;fontStyle=0;verticalAlign=middle;align=center;arcSize=10;" vertex="1" parent="1">
      <mxGeometry x="54" y="406" width="257" height="64" as="geometry" />
    </mxCell>
    <mxCell id="Node6" value="结果：20+类似物；acidsA等活性超鲨鱼角鲨烯" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#f8cecc;strokeColor=#b85450;fontSize=16;fontStyle=0;verticalAlign=middle;align=center;arcSize=10;" vertex="1" parent="1">
      <mxGeometry x="423" y="284" width="313" height="64" as="geometry" />
    </mxCell>
    <mxCell id="Node7" value="结构-活性关系：链长正相关；饱和/负电荷影响" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#f8cecc;strokeColor=#b85450;fontSize=16;fontStyle=0;verticalAlign=middle;align=center;arcSize=10;" vertex="1" parent="1">
      <mxGeometry x="228" y="528" width="320" height="64" as="geometry" />
    </mxCell>
    <mxCell id="Node8" value="结论：可持续萜类为鲨鱼角鲨烯替代品，佐剂性相当或更优" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#fff2cc;strokeColor=#d6b656;fontSize=16;fontStyle=1;verticalAlign=middle;align=center;arcSize=10;" vertex="1" parent="1">
      <mxGeometry x="382" y="406" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="Edge1" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#6c8ebf;" edge="1" parent="1" source="Node1" target="Node2">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="Edge2" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#82b366;" edge="1" parent="1" source="Node2" target="Node4">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="Edge3" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#82b366;" edge="1" parent="1" source="Node1" target="Node3">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="Edge4" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#d79b00;" edge="1" parent="1" source="Node4" target="Node5">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="Edge5" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#d79b00;" edge="1" parent="1" source="Node3" target="Node6">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="Edge6" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#d79b00;" edge="1" parent="1" source="Node5" target="Node7">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="Edge7" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;strokeColor=#b85450;" edge="1" parent="1" source="Node6" target="Node8">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="Edge8" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0;exitY=0.5;exitDx=0;exitDy=0;entryX=0;entryY=0.5;entryDx=0;entryDy=0;dashed=1;dashed=1;strokeColor=#b85450;" edge="1" parent="1" source="Node7" target="Node8">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
  </root>
</mxGraphModel></diagram></mxfile>