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    <mxCell id="node2" value="策略：&lt;br&gt;基因克隆→序列分析→原核表达→&lt;br&gt;瞬时过表达（同源+异源）+&lt;br&gt;他汀类抑制剂正反验证" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#ffe6cc;strokeColor=#d79b00;fontSize=12;fontStyle=1;verticalAlign=middle;align=center;" vertex="1" parent="1">
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    <mxCell id="node3" value="关键改造（一）：&lt;br&gt;OkHMR基因克隆与蛋白表征&lt;br&gt;ORF:1698bp; 565aa; 60.53kDa;&lt;br&gt;酶动力学参数测定" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#d5e8d4;strokeColor=#82b366;fontSize=11;verticalAlign=middle;align=center;" vertex="1" parent="1">
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    <mxCell id="node4" value="关键改造（二）：&lt;br&gt;瞬时过表达于同源(4种Ocimum)&lt;br&gt;与异源(A.annua, W.somnifera)&lt;br&gt;植物体系" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#d5e8d4;strokeColor=#82b366;fontSize=11;verticalAlign=middle;align=center;" vertex="1" parent="1">
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    <mxCell id="node5" value="关键验证：&lt;br&gt;他汀类抑制剂(pravastatin/mevastatin)&lt;br&gt;处理反转OkHMR效果，&lt;br&gt;精油与代谢物含量恢复下降" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#f8cecc;strokeColor=#b85450;fontSize=11;verticalAlign=middle;align=center;" vertex="1" parent="1">
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    <mxCell id="node6" value="主要结果：&lt;br&gt;同源过表达→倍半萜显著增加&lt;br&gt;(β-石竹烯↑37.87%, germacrene A↑75%)&lt;br&gt;异源过表达→青蒿素↑7.4%,&lt;br&gt;醉茄内酯↑44%, 类胡萝卜素↑33%" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#e1d5e7;strokeColor=#9673a6;fontSize=11;verticalAlign=middle;align=center;" vertex="1" parent="1">
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    <mxCell id="node7" value="结论：&lt;br&gt;OkHMR是MVA途径关键调控酶，&lt;br&gt;促进单萜、倍半萜、三萜及&lt;br&gt;类胡萝卜素合成，&lt;br&gt;可作为代谢工程工具" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#fff2cc;strokeColor=#d6b656;fontSize=12;fontStyle=1;verticalAlign=middle;align=center;" vertex="1" parent="1">
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    <mxCell id="node8" value="关键数据补充：&lt;br&gt;组织表达：花中最高；盐胁迫上调4–24倍&lt;br&gt;同源中OkHMR表达↑2.1–5.36倍&lt;br&gt;异源中表达↑2.8–3.5倍" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#e6f2ff;strokeColor=#6c8ebf;fontSize=11;verticalAlign=middle;align=center;" vertex="1" parent="1">
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