<mxfile host="app.diagrams.net"><diagram name="roadmap"><mxGraphModel dx="1200" dy="800" grid="1" gridSize="10" guides="1" tooltips="1" connect="1" arrows="1" fold="1" page="1" pageScale="1" pageWidth="1200" pageHeight="800" math="0" shadow="0">
  <root>
    <mxCell id="0" />
    <mxCell id="1" parent="0" />
    <mxCell id="problem" value="热胁迫下灵芝酸合成的调控机制不清楚" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#FFE6CC;strokeColor=#D79B00;fontSize=12;fontStyle=1;fontFamily=SimHei;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="78" y="40" width="264" height="64" as="geometry" />
    </mxCell>
    <mxCell id="pld" value="PLD催化产生PA（磷脂酸）" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#D5E8D4;strokeColor=#82B366;fontSize=12;fontStyle=1;fontFamily=SimHei;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="105" y="162" width="210" height="64" as="geometry" />
    </mxCell>
    <mxCell id="pa" value="PA直接结合mTOR（FRB结构域）" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#D5E8D4;strokeColor=#82B366;fontSize=12;fontStyle=1;fontFamily=SimHei;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="102" y="284" width="215" height="64" as="geometry" />
    </mxCell>
    <mxCell id="mtor" value="mTOR激活并促进SREBP加工" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#DAE3F3;strokeColor=#6C8EBF;fontSize=12;fontStyle=1;fontFamily=SimHei;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="105" y="406" width="210" height="64" as="geometry" />
    </mxCell>
    <mxCell id="srebp" value="N-SREBP上调生物合成关键基因" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#DAE3F3;strokeColor=#6C8EBF;fontSize=12;fontStyle=1;fontFamily=SimHei;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="102" y="528" width="215" height="64" as="geometry" />
    </mxCell>
    <mxCell id="edge1" edge="1" source="problem" target="pld" parent="1" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="edge2" edge="1" source="pld" target="pa" parent="1" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="edge3" edge="1" source="pa" target="mtor" parent="1" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="edge4" edge="1" source="mtor" target="srebp" parent="1" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="result" value="GA含量增加约1.89倍，靶基因hmgs/mk/sqs/lss被SREBP结合并激活" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#FFF2CC;strokeColor=#D6B656;fontSize=12;fontStyle=1;fontFamily=SimHei;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="40" y="650" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="edge5" edge="1" source="srebp" target="result" parent="1" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
    <mxCell id="conclusion" value="结论：热胁迫下PLD-PA-mTOR-SREBP级联促进灵芝酸合成" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#F8CECC;strokeColor=#B85450;fontSize=12;fontStyle=1;fontFamily=SimHei;verticalAlign=middle;align=center;" vertex="1" parent="1">
      <mxGeometry x="40" y="772" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="edge6" edge="1" source="result" target="conclusion" parent="1" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;">
      <mxGeometry relative="1" as="geometry" />
    </mxCell>
  </root>
</mxGraphModel></diagram></mxfile>