<mxfile host="app.diagrams.net"><diagram name="roadmap"><mxGraphModel>
  <root>
    <mxCell id="0" />
    <mxCell id="1" parent="0" />
    <mxCell id="2" value="研究背景：1987年C5-C20萜类生物合成综述" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="224" y="40" width="292" height="64" as="geometry" />
    </mxCell>
    <mxCell id="3" value="研究策略：按碳数分类，结合同位素标记、酶学、基因克隆" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="200" y="162" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="4" value="甲羟戊酸上游：HMG-CoA合酶/还原酶及IPP异构酶调控" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="200" y="284" width="340" height="64" as="geometry" />
    </mxCell>
    <mxCell id="5" value="单萜合酶机制：异构化-环化及同位素效应研究" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="44" y="406" width="313" height="64" as="geometry" />
    </mxCell>
    <mxCell id="6" value="倍半萜合成：FPP合酶立体化学与广藿香醇机制" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="40" y="528" width="313" height="64" as="geometry" />
    </mxCell>
    <mxCell id="7" value="二萜合成：GGPP合酶及kaurene合酶表征" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="426" y="406" width="271" height="64" as="geometry" />
    </mxCell>
    <mxCell id="8" value="氧化修饰酶：P450加氧酶与赤霉素氧化酶" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="423" y="528" width="278" height="64" as="geometry" />
    </mxCell>
    <mxCell id="9" value="下游代谢：保幼激素酯酶及其他相关酶" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="238" y="650" width="264" height="64" as="geometry" />
    </mxCell>
    <mxCell id="10" value="结论：深化萜类碳骨架形成机制的理解" vertex="1" parent="1" style="rounded=1;whiteSpace=wrap;html=1;verticalAlign=middle;align=center;">
      <mxGeometry x="238" y="772" width="264" height="64" as="geometry" />
    </mxCell>
    <mxCell id="e1" edge="1" parent="1" source="2" target="3" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;"><mxGeometry relative="1" as="geometry" /></mxCell>
    <mxCell id="e2" edge="1" parent="1" source="3" target="4" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;"><mxGeometry relative="1" as="geometry" /></mxCell>
    <mxCell id="e3" edge="1" parent="1" source="4" target="5" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;"><mxGeometry relative="1" as="geometry" /></mxCell>
    <mxCell id="e4" edge="1" parent="1" source="5" target="6" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;"><mxGeometry relative="1" as="geometry" /></mxCell>
    <mxCell id="e5" edge="1" parent="1" source="4" target="7" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;"><mxGeometry relative="1" as="geometry" /></mxCell>
    <mxCell id="e6" edge="1" parent="1" source="5" target="7" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=1;exitY=0.5;exitDx=0;exitDy=0;entryX=0;entryY=0.5;entryDx=0;entryDy=0;"><mxGeometry relative="1" as="geometry" /></mxCell>
    <mxCell id="e7" edge="1" parent="1" source="6" target="7" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0;exitY=0.5;exitDx=0;exitDy=0;entryX=0;entryY=0.5;entryDx=0;entryDy=0;dashed=1;dashed=1;dashed=1;dashed=1;dashed=1;"><mxGeometry relative="1" as="geometry" /></mxCell>
    <mxCell id="e8" edge="1" parent="1" source="7" target="8" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;"><mxGeometry relative="1" as="geometry" /></mxCell>
    <mxCell id="e9" edge="1" parent="1" source="8" target="9" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;"><mxGeometry relative="1" as="geometry" /></mxCell>
    <mxCell id="e10" edge="1" parent="1" source="9" target="10" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;"><mxGeometry relative="1" as="geometry" /></mxCell>
    <mxCell id="e11" edge="1" parent="1" source="6" target="9" style="edgeStyle=orthogonalEdgeStyle;rounded=1;orthogonalLoop=1;jettySize=auto;html=1;endArrow=block;endFill=1;strokeWidth=1.6;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0.5;entryY=0;entryDx=0;entryDy=0;"><mxGeometry relative="1" as="geometry" /></mxCell>
  </root>
</mxGraphModel></diagram></mxfile>